KOLLIPHOR P188 CELL CULTURE

BASF’s Kolliphor P grade poloxamers are white, coarse - grained powders with a waxy consistency. They contain an appropriate quantity of the antioxidant BHT. Poloxamers are ABA-type co-polymers of poly (ethylene oxide) (PEO=A) and poly (propylene oxide) (PPO=B). The approximate relative amount of PEO and the average molecular weight of the PPO are indicated in the name of the poloxamer. For example, P 188 succeeding the word Kolliphor® indicates a poloxamer with ca. 80% m/m PEO (P 188; 8x10= 80%) and approximately average molecular weight of PPO of 1800 (P 188; 18x100= 1800). Kolliphor® P 188 Bio & Kolliphor® P 188 Cell Culture are designed for protection against shear stress in biologic drug manufacturing processes. It is also suitable as an excipient for parenteral formulations. Improvements in the manufacturing process and a validated RP-HPLC assay ensures the highest quality product for consistent performance and less variability versus other poloxamer 188 grades.